Skip to Content

PO BOX 683148 | Houston, TX 77268 | ph 888-247-8700 | fx 888-247-8706

NPTA is the largest professional society for pharmacy technicians. Membership is open to pharmacy technicians, students, and educators. more...

3-Mar-11 2:00 PM  CST  

Ibuprofen May Lower Risk of Parkinson's Disease 

Taking ibuprofen regularly may help reduce the risk of Parkinson’s disease, according to a new study published in the March 2 online issue of Neurology.

Researchers from Harvard Medical School examined the medical histories of over 136,000 men and women over a six-year period. After six years, 291 participants were diagnosed with Parkinson’s. According to the study, participants who took ibuprofen two or more times per week were 38 percent less likely to develop Parkinson’s than those who didn’t. When researchers compared their findings with previous studies, they found that the patients who took ibuprofen regularly were 27 percent less likely to develop Parkinson’s compared to those taking other NSAIDS and acetaminophen.

While researchers are not sure exactly why patients on ibuprofen were at lowest risk for Parkinson’s, Dr. Xiang Gao, M.D., Ph.D., the study’s lead researcher, suspects that the ibuprofen targets a receptor in the brain that linked to swelling, which can trigger Parkinson’s. The receptor has been linked to the onset of Parkinson’s disease in animal studies.

"One possibility as to why ibuprofen may have this effect against Parkinson's disease is that it may target a certain receptor in the brain called the peroxisome proliferator-activated receptor y (PPARy). Studies in animals have also suggested this effect," Gao said in a release issued by the American Academy of Neurology (AAN).

Parkinson’s disease is a progressive neurological disorder in which the nerve cells of the brain that produce dopamine are slowly destroyed. The loss of dopamine-producing cells results in tremors, difficulty moving and gradual loss of muscle control. The National Institutes of Health estimates that about 50,000 people are diagnosed with Parkinson’s disease each year.

Even though the study suggested a possible link between ibuprofen and reduced risk of getting Parkinson’s disease, editorial author Dr. James H. Bower, M.D., M.Sc., a member of AAN, said people should not start taking ibuprofen to prevent Parkinson’s just yet. Further clinical research is needed to prove a direct link exists. As with other NSAIDS, he added, ibuprofen comes with an increased risk of stomach bleeding and kidney problems.   

"Long-term ibuprofen use has a lengthy list of risks," Bower said. "Additionally, the use of ibuprofen may not be directly reducing the risk of Parkinson's. It may be related to some other unrecognized factor that is actually reducing the risk."
Copyright © 2011 NPTA. All rights reserved.

Click a star to rate!

Rating: 0.00 / 5.00  - Not yet rated.
0 ratings


Total Comments: 1
  • Cynthia on 5-Mar-11 0:43 AM permalink

    I find it very impressive that it has potential but as the article concluded it does not mean everyone should take it as prophylaxis. The ibuprofen action is not a direct mechanism and the side effects of ibuprofen abuse and its weapons are far more immediate and outweigh the benefits of prophylaxis.

Post a Comment

0 / 500 characters

Add to Favorites


For additional information on this Article article, please contact:

Kristina Michel
(888) 247-8700

Source: NPTANews

Related Documents:

Content Tags:

Tags: AAN cpht Harvard Medical School ibuprofen Neurology NIH npta NSAIDS Parkinsons Parkinsons disease pharmacy pharmacy technician PPARy study


Other Recent Articles:

Return to Pharmacy Technician Articles Search

NPTA is lobbying for pharmacy technician issues, conducting industry-related research, developing benchmark reports, manage a national... more

NPTA is the #1 source for pharmacy technician products.


Are you Prepared? Chemotherapy Certification course